Postmenopausal Hormone Replacement Therapy Increases Coagulation Activity and Fibrinolysis
نویسندگان
چکیده
منابع مشابه
Postmenopausal hormone replacement therapy increases coagulation activity and fibrinolysis.
Hormone replacement therapy (HRT) appears to be cardioprotective in postmenopausal women; however, concerns exist over its thrombogenic effects. To address the effects of combined HRT on coagulation and fibrinolysis, we have measured circulating markers of these processes in a double-blind placebo-controlled trial. Forty-two healthy postmenopausal women aged 50 to 75 years received continuous c...
متن کاملPostmenopausal hormone replacement therapy.
Several comprehensive accounts of postmenopausal hormone replacement treatment have been published in the United Kingdom in the past year`so in this review we concentrate on areas which, while often controversial, are of concern to the practising physician. We discuss the effects of postmenopausal hormone replacement therapy on the risks of developing coronary heart disease, osteoporosis, and c...
متن کاملEffect of estrogen-progestin hormonal replacement therapy on blood coagulation and fibrinolysis in postmenopausal women.
OBJECTIVE To evaluate antithrombin III (AT), thrombin (Fragment 1+2 [F1+2] and thrombin-antithrombin [TAT]) generation markers, as well as other coagulation parameters, such as prothrombin time, partial activated thromboplastin time, thrombin time, fibrinogen, euglobulin lysis time, and platelet count, in postmenopausal women after hormonal therapy. STUDY DESIGN Forty-five patients who receiv...
متن کاملPostmenopausal hormone replacement therapy and cardiovascular disease.
Cardiovascular disease is the leading cause of mortality in postmenopausal women in developed countries. A possible cardioprotective role of hormone replacement therapy (HRT) is suggested by epidemiologic studies of HRT and reduced risk of coronary heart disease, as well as by randomized trials of HRT and lipid subfractions. Estrogen has beneficial effects on the lipid profile, raising high-den...
متن کاملPostmenopausal Hormone Replacement Therapy and Cardiovascular Disease
Heart disease is the leading cause of death among postmenopausal American women. Although early observational studies suggested that hormone replacement therapy (HRT) might decrease these risks, prospective, experimental studies have not supported these results. With the recent release of these data in the media, clinicians are receiving numerous questions concerning HRT. This article reviews t...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2000
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.20.5.1404